Free Agent - EU
As transcendence now stacks with damage I personally prefer the early pen and cooldown from jotunn rather than a slow stack at the beginning of the game. For modes like arena I'd suggest getting jotunn and fail-not first and then transcendence. In so doing you'll get full CD very fast and also stack trans faster.
I'd replace crusher by brawler if antihealing is needed. Also, choose whatever jotunn upgrade you prefer.
Bluestone Brooch
PASSIVE - Enemies hit by your damaging abilities take an additional 160 Physical Damage over 2s. Enemy gods take an additional 10% of their Current Health as Physical Damage over 2s. Subsequent hits on the same target do half the bonus damage for the next 3s.
Jotunn's Wrath
Y10 Evolved Transcendence
PASSIVE - You gain Physical Power equal to 2% of your Maximum Mana.
Fail-not
PASSIVE - When your Ultimate ability has finished casting, your next ability or basic attack within 8s that damages an enemy god marks them, increasing the chance you and your allies can land a Critical Strike by 20% for 10 seconds. This can only occur once every 45 seconds. This item is only available to Hunters.
The Crusher
PASSIVE - Enemies hit by your damaging Abilities take bonus damage equal to an additional 30% of your Physical Power over 1s. Subsequent hits on the same target do half the bonus damage for the next 3s.
Heartseeker
PASSIVE - Your abilities deal an additional 2% of the targets maximum Health as Physical Damage. If you have over 150 Physical Power, your ability bonus damage scales up. This effect reaches a maximum of 6% Maximum Health damage at 250 Physical Power. Subsequent hits on the same target do 75% of the bonus damage for the next 3s.
Temporal Beads
Using this item removes Crowd Control Effects and makes you immune to new ones for 2s. Additionally, your active cooldowns are reduced by 3s on use. Cooldown - 140s.
Aegis of Acceleration
Using this item makes you invulnerable to damage and healing for 1.5s, and prevents you from taking any actions. You may still move. Each instance of damage prevented in this time provides you 7% Movement Speed for 4s, stacking up to 3 times. Cooldown - 140s.