Adjusted from my V1 build to trade some attack speed for more damage in the way of critical chance, and better mana sustain.

I'm going to preface this by saying I am by far not even close to being one of the best or even one of the better Arachne players, I'm not an expert - this is just a god I enjoy playing a lot and in Arena in particular. There are much more knowledgeable players that run Arachne main, this is just a build I've found worked for me and my play style.

This is a build I've devised for Arena play specifically which focuses on leveraging lifesteal/healing buffing and critical chance items to provide high sustain to Arachne while maintaining very high damage output capability. The thought behind this build is every action I perform that damages an enemy should heal me, and as long as I'm on an enemy and not getting dogpiled I can use the enemy to keep me alive as my lifesteal drains them quickly for health. This build does not change the fact that Arachne has a difficult time when enemies group up, but it allows me to play her and stay alive/tank damage that would otherwise kill me. The challenge is to not let the high sustain lull you into a false sense of invincibility and in turn playing dumb and overly aggressive because doing so will get you killed when playing against even non-coordinated groups.