Vampiric Shroud - Easy starter for Artio's 4 abilites. On top of her 2 heals it makes it very hard for you to lose lane. For the most part the axe starter is better on her but for this healing build, this is better

Shoes of Magi - Keep the lifesteal theme going, cooldown isnt worth it on artio at the start, youll just end up running out of mana which is very easy to do on her early, sustain is better

Soul Gem - You can burst an.y.bo.dy with this item. Cooldown Health and lifesteal, and the passive stacks every 4 ABILITIES, and procs on your damaging ability at full stacks. With your 6 abilities on 20% cooldown with blue buff, you proc this veeeeeery easily. It doesnt matter who your fighting in solo, they can no longer box with you, if they do because they dont see the item, they die. Nobody ever sees the damage and heals coming,

Downside - While you have sustain, you have no defense. Even though you can box very well now having this item, maybe even grab a jg kill if he tries to gank, im not sure how well this'll go down in ranked

Pridwen - You dont get to benefit from the passive most the time but the 20% cooldown and 30 magical and physical defense is what you need it for anyway.

Downside -Mana will be an issue at this point, and if you dont always have blue this is gonna be an issue

Rod of Asclepius - Health and bonus healing. Bonus healing for your 1, 3, lifesteal, and all your lifesteal stacks endgame. This along with your soul gem and your 1, you help so much more in team fights.

Downside - Another item that provides health and sustain, but no defense. If you get caught by multiple people by yourself you can get bursted pretty easily

Blood-soaked Shroud - At this point you should be level 20, the stacks of this with your full cooldown (with blue buff) and physical defense make you extremely annoying to fight against

Mantle of Discord - Finish off the last 10 percent of cooldown with a shitload of defense

Stone of Binding - Just a cheap item to finish it off. Once again you dont need anymore damage or sustain so i just get this to get as much defense online as fast as possible

With this build its not too hard to get all top stats in most match ups, but i have yet to try it in ranked which is....testing grounds i guess. Works very very very well in casuals

TLDR

Upside - Full cooldown, infinite sustain, easily run down the back line, 250+ physical defense, really helpful in team fights, probably obtain all top stats

Downside - Long time to get defense up, mana problems midgame, only 168 magical defense and with how hard mages like Janus hit nowadays isnt great