Just a simple and versatile build viable for basically all usual game modes. Polynomicon may be replaced by soul reaver if you want to deal more damage to tanks. I usually go with blink to play aggresive, but sanctuary is the better option for survivability.
Pendulum of Ages
PASSIVE - This item grants 4 MP5 per 10% of your missing Mana. This item grants 7 Magical power per 10% of your available Mana.
Spear of Desolation
PASSIVE - If you receive a kill or assist on an Enemy God all of your non-ultimate cooldowns are reduced by 2 seconds and your ultimate cooldown is reduced by 6 seconds.
Divine Ruin
PASSIVE - Enemies hit by your abilities have 40% reduced healing for 5 seconds. Your next successful damaging ability on an enemy triggers a chain lightning, damaging the target and up to 4 nearby enemies for 40 damage + 10% of your Magical Power. This can only occur once every 20 seconds.
Charon's Coin
PASSIVE - On god kill or assist a coin is flipped. If heads, you gain a stack of 7 HP5. If tails, you gain a stack of 2% Movement Speed. Each effect can stack up to 4 times and at 8 stacks this item evolves. You also gain 15 gold every time the coin is flipped.
Calamitous Rod of Tahuti
PASSIVE - Basic Attacks and Abilities gain 15% additional Magical Power against targets below 60% Health. <n>GLYPH - Successfully hitting an enemy god with an ability calls down a meteor that lands after 1s, dealing 100 (+35% of your Magical Power) damage in a 15 unit radius. This effect can only occur once every 15s.
Y10 Polynomicon
PASSIVE - Using an ability gives your next Basic Attack within the next 8 seconds +75% of your Magical Power as additional Magical Damage. The effect can only apply once every 2 seconds.
Temporal Beads
Using this item removes Crowd Control Effects and makes you immune to new ones for 2s. Additionally, your active cooldowns are reduced by 3s on use. Cooldown - 140s.
Scorching Blink Rune
Using this item will allow you to teleport up to 45 units away instantly, leaving behind a trail of wildfire that burns Enemies that pass through it for 20 (+ 4 per level) True Damage every 0.5s for the next 4s. Additionally, enemies hit have their Movement and Attack Speed Slowed by 15%. These effects persist for 1.5s after leaving the flames. This item can not be used if you have taken or dealt damage in the last 3s. Cooldown - 120s.
Swap the item order as you see fit. I think charon's coin as third item helps a lot with mana sustain. 30% cd early drains your mana a lot, that's why I feel the extra mp5 from charon is better. Plus it stacks sooner.
The Alternate Timeline
PASSIVE - When you would die you instead find a timeline you are still alive, becoming CC Immune, Damage Immune, and unable to act. After 1.75s you are restored to 40% Health and Mana and can act again. This can only occur once every 6 minutes.
Chronos' Pendant
PASSIVE - Every 10s the Pendant activates, subtracting 1s from all of your abilities currently on Cooldown. The initial countdown will not start until you leave the fountain.
Evolved Charon's Coin
PASSIVE - On god kill or assist a coin is flipped. If heads, you gain 150 Health over 6 seconds. If tails, you gain 5% Movement Speed for 6 seconds. You also gain 15 gold every time the coin is flipped.
Spear of Desolation
PASSIVE - If you receive a kill or assist on an Enemy God all of your non-ultimate cooldowns are reduced by 2 seconds and your ultimate cooldown is reduced by 6 seconds.
Divine Ruin
PASSIVE - Enemies hit by your abilities have 40% reduced healing for 5 seconds. Your next successful damaging ability on an enemy triggers a chain lightning, damaging the target and up to 4 nearby enemies for 40 damage + 10% of your Magical Power. This can only occur once every 20 seconds.
Calamitous Rod of Tahuti
PASSIVE - Basic Attacks and Abilities gain 15% additional Magical Power against targets below 60% Health. <n>GLYPH - Successfully hitting an enemy god with an ability calls down a meteor that lands after 1s, dealing 100 (+35% of your Magical Power) damage in a 15 unit radius. This effect can only occur once every 15s.
Temporal Beads
Using this item removes Crowd Control Effects and makes you immune to new ones for 2s. Additionally, your active cooldowns are reduced by 3s on use. Cooldown - 140s.
Scorching Blink Rune
Using this item will allow you to teleport up to 45 units away instantly, leaving behind a trail of wildfire that burns Enemies that pass through it for 20 (+ 4 per level) True Damage every 0.5s for the next 4s. Additionally, enemies hit have their Movement and Attack Speed Slowed by 15%. These effects persist for 1.5s after leaving the flames. This item can not be used if you have taken or dealt damage in the last 3s. Cooldown - 120s.