Editing: 5.13 - Assassin Scylla
For those of you too lazy to view my profile, I pretty much only play Scylla exclusively (though will sometimes dabble with Jing Bae, Athena or Bellona if needed). I typically only play Arena or Clash (since Clash is basically just Arena #2) though I will play Joust and Conquest on occassion. This build is geared towards the more veteran players of Smite and those who are relatively familiar with Scylla's kit. If you are new to Smite or to Scylla then I don't recommend trying this build right out of the gate (though some of it can still be useful).
I will note that this build is in no way absolute or perfect and depending on the team comps you may need to incorporate items not listed here and change up the build or strategy. At the end of the day experience is the #1 teacher in how to be good with a god and Scylla is no different.
One unique aspect of this build is that it is in no way geared towards her Ultimate. While her ult is still incredibly powerful with this build, it instead seeks to make her a terrifying powerhouse capable of killing even the tankiest of gods, even if her ult is on cooldown.
*Note: I have only done some testing of this build on the PTS and is a variation on my current 'Assassin-like' build (the biggest change is the inclusion of the new item [Rangda's Mask]). As such this list is subject to change as I get more play time in the 5.13 patch.
Typically I will throw out [Sic 'Em] first (on minions if possible) and then use the Poly auto on the tower. Throw out 2 or 3 more auto's while Poly comes off cooldown. Once it is ready again throw out [Crush] (on minions if you can) and then use Poly on the tower once more. By now [Sic 'Em] should be up again and you simply rinse and repeat. If you need to retreat then throw [Sentinel] to begin your escape and use one last auto (since Sentinel will proc it). But remember that your life is more important than a tower so if you need to escape, don't worry about one missed auto.
The goal of this build is to make sure you kill the enemy before they kill you (as with any Mage or Assassin). Scylla is already a terrifying force to be reckoned with and this build makes her all the more fearsome. The biggest down side (again, as with any Mage or Assassin) is that they are extremely squishy and once their abilities are used they are pretty much useless. The key to this build is essentially a Full-Kit combo (minus ult). Just keep in mind this combo centers around Polynomicon and will require some timing and practice. I also strongly recommend keeping an eye on the enemy Relics so you know who has Purification or Aegis as this will sometimes affect the combo. Below are the steps to perform this combo as well as some things to keep an eye out for while using it:
This combo is also still an excellent defensive option, so even if you aren't on the offensive, the moment you get a root (or even better if a teammate roots/stuns an enemy) you can quickly turn a fight around with this combo.
As I mentioned earlier, keep in mind that perfecting this combo will take a litle bit of practice as all of those listed steps should happen within the span of 2-3 seconds meaning it will take some quick thinking and judgement to execute correctly. But, once you have it down you'll be able to kill just about anyone you want. With this build I also strongly recommend getting good at tracking when Polynomicon is proc'd/ready to be proc'd. Tracking this item especially important as it is essentially free damage so make sure to know which basic attacks you should be taking extra care to aim. A quick example I will give is one from personal experience. I had just used my full kit and was making my escape. I used Sentinel but as I dashed away it turned out that a He Bo was on our backline. He was still at about 40% HP while I was slightly lower. He pursued with Atlas but I knew that Poly was ready for use as it was proc'd by my Sentinel. I threw out my auto which landed true and was able to 1-shot him.
Select the cards for the main build first. Then you'll be able to add situational builds.